What is the evidence that pregnancy increases the risk of pouchitis in patients with IPAA

What is known

- A cohort study reports acute pouchitis is common in pregnant and postpartum women after total proctocolectomy with IPAA. ¹ - The authors state a large prospective registry of pregnant IPAA patients is needed to confirm these findings and inform recommendations. ¹ - Evidence to guide pouchitis management during pregnancy and postpartum is described as scarce, and guidelines do not specifically address it. ¹

What is unknown / caveats

- Pregnancy/disease-activity studies broadly show conflicting results with little consistency in measured variables ², but no retrieved study directly refutes a pregnancy-pouchitis association - Single cohort on pregnancy-related pouchitis; no directly opposing study in the retrieved set - No excerpt quantifies whether pregnancy independently increases pouchitis risk versus baseline rates - Whether pregnancy is an independent risk factor for pouchitis, as opposed to reflecting background high pouchitis incidence, is not resolved by these excerpts.

## References

1. Kayal M, Gottlieb Z, Glamour B, Ibing S, Spencer E, Dubinsky MC. Acute Pouchitis is Common in Pregnant and Postpartum Women. Clin Transl Gastroenterol. 2024;15:e00732. PMID: 38976322.

2. Selinger CP, Nelson-Piercy C, Fraser A, Hall V, Limdi J, Smith L, Smith M, Nasur R, Gunn M, King A, Mohan A, Mulgabal K, Kent A, Kok KB, Glanville T. IBD in pregnancy: recent advances, practical management. Frontline Gastroenterol. 2021;12(3):214-224. PMID: 33912333.

For educational use only, not a substitute for clinical judgement or medical advice. Consult qualified clinicians for diagnosis and treatment decisions. This tool may contain errors; use the flag button below to report inaccurate or harmful content.

---

_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._