What is the rate of anastomotic leak after laparoscopic total colectomy with IPAA in patients with UC

What is known

- In a 75-case transanal modified two-stage IPAA series, anastomotic leak occurred in 8 patients (10.6%). ¹ - Reported leak rates after modified two-stage IPAA range from 4.6% to 17%; one study found similar rates in diverted vs non-diverted IPAA (16.7% vs 17.1%). ¹ - A multicentre prospective IPAA registry (62 patients) reported an anastomotic leak rate of 8%. ¹

What is unknown / caveats

- Leak-rate figures come mainly from a single transanal modified two-stage series, not a pure laparoscopic total colectomy cohort - Reported comparison series included substantial proportions of three-stage procedures (80% and 40.3%), which may affect leak rates - No excerpt reports a definition-standardized or adequately powered comparison of leak rates across techniques - The excerpts do not isolate a leak rate specific to laparoscopic (as opposed to transanal) total colectomy with IPAA.

## References

1. Bislenghi G, Martin-Perez B, Fieuws S, Wolthuis A, D'Hoore A. Increasing experience of modified two-stage transanal ileal pouch-anal anastomosis for therapy refractory ulcerative colitis. What have we learned? A retrospective analysis on 75 consecutive cases at a tertiary referral hospital. Colorectal Dis. 2021;23:74-83. PMID: 32619321.

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_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._